Sodium Hydroxide → HCID 178481206, compound

HRID 1637924Notes

Reaction equation

HRID 1637924 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[NH2:24][C:25]1[CH:26]=[CH:27][C:28]2[N:32]=[CH:31][N:30]([CH3:33])[C:29]=2[CH:34]=1.[OH-].[Na+]>CN(C=O)C.CO>[CH3:33][N:30]1[C:29]2[CH:34]=[C:25]([NH:24]/[C:13](=[C:6]3\[C:5](=[O:23])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[CH:10][CH:11]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:26]=[CH:27][C:28]=2[N:32]=[CH:31]1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 136802831-Methyl-1H-benzimidazol-6-amineHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178481206HCID 178481206, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared from 1-acetyl-3-{1-ethoxy-1-phenylmethylidene}-2-indolinone and 2 equivalents of 6-amino-1-methyl-benzimidazole, melting point 163-165° C., in DMF followed by treatment with 1N sodium hydroxide solution in MeOH.

Sources & evidence

ORD record
ord-d30f9678d6304bb78a173a9ffab48b31
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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