Water → HCID 178481341, compound

HRID 1637929Notes

Reaction equation

C(O[C:4](=[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[NH:13][C:12]1=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)C.[CH3:24][N:25]1[C:34](=[O:35])[C:33]([CH3:37])([CH3:36])[C:32]2[C:27](=[CH:28][C:29]([NH2:38])=[CH:30][CH:31]=2)[C:26]1=[O:39].O>CN(C=O)C>[CH3:24][N:25]1[C:34](=[O:35])[C:33]([CH3:37])([CH3:36])[C:32]2[C:27](=[CH:28][C:29]([NH:38]/[C:4](=[C:11]3\[C:12](=[O:23])[NH:13][C:14]4[C:19]\3=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=4)/[C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)=[CH:30][CH:31]=2)[C:26]1=[O:39]

Participants

Conditions

Temperature: 120 °C

Procedure

Prepared from 3-(1-ethoxy-1-phenylmethylidene)-5-nitro-2-indolinone and 1.5 equivalents of 2-methyl-7-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline, melting point 169-171° C., in DMF by heating to 120° C. for 1 hour, pouring into water, filtering and washing the precipitate with MeOH and ether.

Workup

filtrationfiltering
washwashing the precipitate with MeOH and ether

Sources & evidence

ORD record: ord-e4b8c969be56409d93c338e89eb08acb
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043254

Reaction notes

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