Methyl iodide → 1-methyl-4-(4-nitrophenyl)-1H-imidazole

HRID 1637935Notes

Reaction equation

HRID 1637935 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][NH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[K].[CH3:16]C(C)([O-])C.CI>CS(C)=O>[CH3:16][N:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 50987170Potassium tertbutoxideHCID 178418805HCID 178418805, compound

Product 1

HCID 188004741-methyl-4-(4-nitrophenyl)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared by reacting 4-(4-nitro-phenyl)-imidazole in DMSO with potassium-tert.butoxide at 0° C. and then with methyliodide at 20-25° C.

Workup

  1. customPrepared
  2. customat 0° C.
  3. customat 20-25° C.

Sources & evidence

ORD record
ord-d0f1bbea951146c8a5e26bb695dd3931
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

Loading…