HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → HCID 178473964, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 4-(Trifluoromethyl)benzoic acid | HCID 9966 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Edukt | 1-Acetyl-5-nitroindolin-2-one | HCID 2839329 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | HCID 178473964 | HCID 178473964 | — |
Reaktionsschritte
Prepared by reacting 1-acetyl-5-nitro-2-indolinone with one equivalent of 4-trifluoromethyl-benzoic acid in dry DMF in the presence of 1 equivalent each of TBTU and HOBT and 5 equivalents of Huinig's base (20° C., 4 hours), stirring into dilute hydrochloric acid, filtering the precipitate, dissolving the precipitate in EtOac, drying the organic phase and evaporation in vacuo and purifying the evaporation residue by column chromatography on silica gel with CH2Cl2 /MeOH (10:1) as eluant.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06043254 |
| Quelldatensatz | uspto-grants-2000_03 |
| ORD ID | ord-ced276462a764a7a8b4fce8abba231b5 |
| Quellennotiz | uspto-grants-2000_03 |