反应详情

Prepared by reacting 1-acetyl-5-nitro-2-indolinone with one equivalent of 4-trifluoromethyl-benzoic acid in dry DMF in the presence of 1 equivalent each of TBTU and HOBT and 5 equivalents of Huinig's base (20° C., 4 hours), stirring into dilute hydrochloric acid, filtering the precipitate, dissolving the precipitate in EtOac, drying the organic phase and evaporation in vacuo and purifying the evaporation residue by column chromatography on silica gel with CH2Cl2 /MeOH (10:1) as eluant.

1. customPrepared
2. filtrationfiltering the precipitate
3. dissolutiondissolving the precipitate in EtOac
4. customdrying
5. customthe organic phase and evaporation in vacuo
6. custompurifying the evaporation residue by column chromatography on silica gel with CH2Cl2 /MeOH (10:1) as eluant