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HRID1637956

反应详情

EQUATION

反应方程式

HRID 1637956 的结构方程式

REACTANTS

反应物

5
结构：Cc1ccc(C(=O)O)cc1
HCID7470

4-Methylbenzoic acid

C8H8O2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：CC(=O)N1C(=O)Cc2cc([N+](=O)[O-])ccc21
HCID2839329

1-Acetyl-5-nitroindolin-2-one

C10H8N2O4

PRODUCTS

生成物

1
结构：CC(=O)N1C(=O)C(=C(O)c2ccc(C)cc2)c2cc([N+](=O)[O-])ccc21
HCID178473962

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 10(a) from 1-acetyl-5-nitro-2-indolinone and 4-methyl-benzoic acid in dry DMF in the presence of TBTU, HOBT and Hunig's base (20° C., overnight) and final purification by column chromatography on silica gel with CH2Cl2 as eluant.

WORKUP

后处理

  1. customfinal purification by column chromatography on silica gel with CH2Cl2 as eluant