HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178473947, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Acetyl-3-[1-chloro-1-(4-phthalimidomethyl-phenyl)-methylidene]-5-nitro-2-indolinone | HCID 69741019 | — |
| Reactant | HCID 178507418 | HCID 178507418 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178473947 | HCID 178473947 | — |
Reaction Steps
A solution of 0.50 g (1 mmol) of the chlorine compound obtained in (b) in 20 ml of CH2Cl2 is added to a cold (Ti =-60° C.) stirred suspension of 0.35 g (1.5 mmol) of 4-(1H-imidazol-4-yl)aniline×2 HCl (melting point: 350° C.) and 0.77 ml (4.5 mmol) of Hunig's base in 20 ml CH2Cl2 and stirred overnight at ambient temperature. After evaporation in vacuo and evaporation twice with toluene in vacuo the residue obtained is triturated with EtOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043254 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-f85a375c3dde4832af1ff2ea7be1bda6 |
| Source note | uspto-grants-2000_03 |