HRID1637964

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID24526

Chlorine

Cl2

HCID81531

Diisopropylethylamine

C8H19N

结构：CC(=O)N1C(=O)C(=C(Cl)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21

HCID69741019

未命名化合物

HCID178507418

未命名化合物

PRODUCTS

生成物

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(-c3c[nH]cn3)cc2)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2cc([N+](=O)[O-])ccc21$

HCID178473947

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

A solution of 0.50 g (1 mmol) of the chlorine compound obtained in (b) in 20 ml of CH2Cl2 is added to a cold (Ti =-60° C.) stirred suspension of 0.35 g (1.5 mmol) of 4-(1H-imidazol-4-yl)aniline×2 HCl (melting point: 350° C.) and 0.77 ml (4.5 mmol) of Hunig's base in 20 ml CH2Cl2 and stirred overnight at ambient temperature. After evaporation in vacuo and evaporation twice with toluene in vacuo the residue obtained is triturated with EtOH.

WORKUP

后处理

additionis added to a cold (Ti =-60° C.)
stirringstirred overnight at ambient temperature
customAfter evaporation
customin vacuo and evaporation twice with toluene in vacuo the residue
customobtained
customis triturated with EtOH

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f85a375c3dde4832af1ff2ea7be1bda6
来源数据集: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06043254
来源说明: uspto-grants-2000_03

反应 SMILES

ClCl.[C:3]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([N+:15]([O-:17])=[O:16])=[CH:12][CH:13]=2)[C:8](=[C:18](Cl)[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:26]3[C:30](=[O:31])[C:29]4=[CH:32][CH:33]=[CH:34][CH:35]=[C:28]4[C:27]3=[O:36])=[CH:21][CH:20]=2)[C:7]1=[O:38])(=[O:5])[CH3:4].[NH:39]1[CH:43]=[C:42]([C:44]2[CH:50]=[CH:49][C:47]([NH2:48])=[CH:46][CH:45]=2)[N:41]=[CH:40]1.Cl.CCN(C(C)C)C(C)C>C(Cl)Cl>[C:3]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([N+:15]([O-:17])=[O:16])=[CH:12][CH:13]=2)/[C:8](=[C:18](/[NH:48][C:47]2[CH:46]=[CH:45][C:44]([C:42]3[N:41]=[CH:40][NH:39][CH:43]=3)=[CH:50][CH:49]=2)\[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:26]3[C:30](=[O:31])[C:29]4=[CH:32][CH:33]=[CH:34][CH:35]=[C:28]4[C:27]3=[O:36])=[CH:21][CH:20]=2)/[C:7]1=[O:38])(=[O:5])[CH3:4]