2-Methylvaleric acid → HCID 178442264, compound

HRID 1637970Notes

Reaction equation

HRID 1637970 reaction equation
C([O:4][C:5]1[C:6](=[O:16])[C:7]2[C:12]([C:13](=[O:15])[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)(=O)C.[CH3:17][CH:18]([CH2:22][CH2:23][CH3:24])C(O)=O>>[OH:4][C:5]1[C:6](=[O:16])[C:7]2[C:12]([C:13](=[O:15])[C:14]=1[CH:18]([CH3:17])[CH2:22][CH2:23][CH3:24])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

3

Reactant 2

HCID 73412-Methylvaleric acidHCID 745131,4-Naphthalenedione, 2-(acetyloxy)-

Product 1

HCID 178442264HCID 178442264, compoundYield 43.4%

Procedure

The method of Example 1 was followed using 2-acetyloxynaphthalene-1,4-dione (1.24 g, 5.74 mmol) and 2-methylpentanoic acid (1.00 g) yielded the title compound (608 mg) after hydrolysis in. 30 ml THF using potassium hydroxide (5×exess) in water (8 ml) (mp 82-83° C.). This compound is listed as compound 3 in the Tables below.

Sources & evidence

ORD record
ord-b357fdd3862349cf8d4482da8c07d957
Source dataset
uspto-grants-2000_03
Patent number
US06043286

Reaction notes

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