Bromine → HCID 19347469, compound

HRID 1638168Notes

Reaction equation

HRID 1638168 reaction equation
[BrH:1].[C:2]1([C:8]2[N:9]=[C:10]3[N:14]([CH:15]=2)[C:13]2[CH2:16][CH2:17][CH2:18][C:19](=[O:20])[C:12]=2[S:11]3)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrBr>Br>[BrH:1].[Br:1][CH:18]1[CH2:17][CH2:16][C:13]2[N:14]3[CH:15]=[C:8]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[N:9]=[C:10]3[S:11][C:12]=2[C:19]1=[O:20]

Participants

4

Reactant 2

HCID 24408BromineHCID 19347458HCID 19347458, compound

Product 1

HCID 19347469HCID 19347469, compoundYield 186.5%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
75 °C

Procedure

2-Phenyl-5,6-dihydroimidazo[2,1-b]benzothiazole-8(7H)-one hydrobromide (11.2 g) was placed into conc. hydrobromic acid (130 ml), and bromine (18.2 ml) was added dropwise to the reaction mixture while maintaining the temperature of 70-80° C. The reaction mixture was stirred at the same temperature for 2 hours, cooled, and washed with cold water to give yellow titled compound (12.8 g, 93%).

Workup

  1. additionwas added dropwise to the reaction mixture
  2. temperaturecooled
  3. washwashed with cold water

Sources & evidence

ORD record
ord-a57f8ba1e8974395831841a0360df2d5
Source dataset
uspto-grants-2000_03
Patent number
US06043373

Reaction notes

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