Bromine → HCID 19347464, compound

HRID 1638177Notes

Reaction equation

HRID 1638177 reaction equation
[BrH:1].[C:2]([C:5]1[S:6][C:7]2[C:13](=[O:14])[CH2:12][CH2:11][CH2:10][C:8]=2[N:9]=1)(=[NH:4])[NH2:3].BrBr>Br>[C:2]([C:5]1[S:6][C:7]2[C:13](=[O:14])[CH:12]([Br:1])[CH2:11][CH2:10][C:8]=2[N:9]=1)(=[NH:3])[NH2:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 19347462HCID 19347462, compound

Product 1

HCID 19347464HCID 19347464, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

2-Bromo-1,3-cyclohexadione prepared in Example 1, Route 1 (A) was reacted with amidinothiourea in the similar manner to that of Example 1, Route 1(B) to give 2-amidino-4,5-dihydrobenzothiazole-7(6H)-one hydrobromide. The hydrobromide (3.4 g) was dissolved into conc. hydrobromic acid (20 ml), and one equivalent of bromine was added dropwise at a temperature of 85° C. The mixture was stirred at a temperature of 80° C. to 90° C. for 30 minutes, cooled and filtered. The solids were neutralized with sodium carbonate to give the titled compound (3.17 g, 67%).

Workup

  1. additionwas added dropwise at a temperature of 85° C
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-e4fbd2ecec214cb082dd7fc1e38fb1ad
Source dataset
uspto-grants-2000_03
Patent number
US06043373

Reaction notes

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