Isopropylamine → HCID 14391438, compound

HRID 1638242Notes

Reaction equation

HRID 1638242 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[NH:20][C:21]([C:23]1[CH:33]=[CH:32][C:26]([O:27][CH2:28][C:29](Cl)=[O:30])=[CH:25][CH:24]=1)=[O:22]>O1CCOCC1>[CH:1]([NH:4][C:29](=[O:30])[CH2:28][O:27][C:26]1[CH:32]=[CH:33][C:23]([C:21](=[O:22])[NH:20][C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([Cl:19])[C:13]=2[Cl:12])=[CH:24][CH:25]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 14391421HCID 14391421, compound

Product 1

HCID 14391438HCID 14391438, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.71 g of isopropylamine and 3.0 g of triethylamine were dissolved in 20 ml of dioxane. To this solution, a solution prepared by dissolving 4-(2,3-dichlorophenyl-carbamoyl)-phenoxyacetyl chloride prepared in the same manner as in Example 3 in 5 ml of dioxane, was dropwise added over a period of about 5 minutes at room temperature under stirring. After completion of the dropwise addition, the stirring was continued at room temperature for further 5 hours. After completion of the reaction, the reaction solution was treated in the same manner as in Example 3 to obtain 3.8 g of desired N-isopropyl-4-(2,3-dichlorophenyl-carbamoyl)-phenoxyacetamide.

Workup

  1. customTo this solution, a solution prepared
  2. additionwas dropwise added over a period of about 5 minutes at room temperature
  3. additionAfter completion of the dropwise addition
  4. customAfter completion of the reaction
  5. additionthe reaction solution was treated in the same manner as in Example 3

Sources & evidence

ORD record
ord-9da583da244a4620a611e667334da5fd
Source dataset
uspto-grants-1989_11
Patent number
US04878942

Reaction notes

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