2-(2-Methoxyphenyl)-1,3-thiazole-4-carboxylic acid → HCID 178489364, compound

Participants

Reaction Steps

A solution of 2-(2-methoxyphenyl)-4-thiazolecarboxylic acid (250 mg) and N,N'-carbonyldimidazole (CDI, 207 mg) in dry DMF (2.5 ml) was allowed to react with stirring at room temperature for 1 hour. Then a solution of 5-aminotetrazole (109 mg) in dry DMF (1.5 ml) was added dropwise thereto and allowed to react at 70° C. for 2 hours. The solvent was removed from the mixture, and the residue was treated with water and acidified with 2N-HCl. The produced solids were filtered, washed with water, treated with stirring with ether, filtered again and dried to give white solids of the desired 2-(2-methoxyphenyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide (255 mg, 79%).

Provenance & Evidence