反应详情

A solution of 2-(2-methoxyphenyl)-4-thiazolecarboxylic acid (250 mg) and N,N'-carbonyldimidazole (CDI, 207 mg) in dry DMF (2.5 ml) was allowed to react with stirring at room temperature for 1 hour. Then a solution of 5-aminotetrazole (109 mg) in dry DMF (1.5 ml) was added dropwise thereto and allowed to react at 70° C. for 2 hours. The solvent was removed from the mixture, and the residue was treated with water and acidified with 2N-HCl. The produced solids were filtered, washed with water, treated with stirring with ether, filtered again and dried to give white solids of the desired 2-(2-methoxyphenyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide (255 mg, 79%).

1. customto react
2. customto react at 70° C. for 2 hours
3. customThe solvent was removed from the mixture
4. additionthe residue was treated with water
5. filtrationThe produced solids were filtered
6. washwashed with water
7. additiontreated
8. stirringwith stirring with ether
9. filtrationfiltered again
10. customdried