Ethanolamine → HCID 178511456, compound

HRID 1638320Notes

Reaction equation

HRID 1638320 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]([NH:15][C:16]2[NH:20][N:19]=[N:18][N:17]=2)=[O:14])[N:12]=1.NCCO>CO>[NH2:12][CH2:11][CH2:13][OH:14].[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]([NH:15][C:16]2[NH:20][N:19]=[N:18][N:17]=2)=[O:14])[N:12]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 178522727HCID 178522727, compound

Product 1

HCID 178511456HCID 178511456, compoundYield 107.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-(2-hydroxyphenyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide (200 mg) in dry methanol (15 ml) was added 2-aminoethanol (0.045 ml) and allowed to dissolve. After allowing for additional 30 minutes at room temperature, the produced solids was filtered and washed with dry ether and then with dry acetone. The filtrate was concentrated and the residue was crystallized by adding dry ether. These crystals wrere combined and dried to give white solids of 2-(2-hydroxyphenyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide 2-aminoethanol salt (130 mg, 54%).

Workup

  1. dissolutionto dissolve
  2. filtrationthe produced solids was filtered
  3. washwashed with dry ether
  4. concentrationThe filtrate was concentrated
  5. customthe residue was crystallized
  6. additionby adding dry ether
  7. customdried

Sources & evidence

ORD record
ord-d3b924e9b38c476a9edbf768efe89b66
Source dataset
uspto-grants-1989_11
Patent number
US04879295

Reaction notes

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