Ethanolamine → HCID 178511457, compound

HRID 1638325Notes

Reaction equation

HRID 1638325 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][CH:8]=[C:9]([C:11]([NH:13][C:14]2[NH:18][N:17]=[N:16][N:15]=2)=[O:12])[N:10]=1.NCCO>CO>[NH2:10][CH2:6][CH2:2][OH:1].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][CH:8]=[C:9]([C:11]([NH:13][C:14]2[NH:18][N:17]=[N:16][N:15]=2)=[O:12])[N:10]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 178522728HCID 178522728, compound

Product 1

HCID 178511457HCID 178511457, compoundYield 162.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-(2-furyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide (100 mg) in dry methanol (10 ml) was added 2 -aminoethanol (0.025 ml) and allowed to react, after dissolving, at room temperature for 30 minutes. Then the solvent was removed from the reaction mixture and the residue was crystallized by triturating with dry ether. The produced crystals were filtered with suction and dried to give yellow solids of 2-(2-furyl)-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide 2-aminoethanol salt (100.3 mg, 81%), m.p. 255°-260° C.

Workup

  1. customto react
  2. dissolutionafter dissolving, at room temperature for 30 minutes
  3. customThen the solvent was removed from the reaction mixture
  4. customthe residue was crystallized
  5. customby triturating with dry ether
  6. filtrationThe produced crystals were filtered with suction
  7. customdried

Sources & evidence

ORD record
ord-782588f3f675428c84600794d8c27ec2
Source dataset
uspto-grants-1989_11
Patent number
US04879295

Reaction notes

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