HCID 86743492, compound → HCID 70387927, compound

HRID 1638334Notes

Reaction equation

HRID 1638334 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][CH:11]([O:22][C:23](=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:12]([O:14]CC1C=CC=CC=1)=[O:13].[H][H]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][CH:11]([O:22][C:23](=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:12]([OH:14])=[O:13]

Participants

5

Reactant 2

HCID 86743492HCID 86743492, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70387927HCID 70387927, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

20 grams of ester IV (0.045 mol) obtained as in Example 1 were dissolved in 200 ml of ethyl acetate and, after adding 2 g of 10% palladium on carbon, were treated with hydrogen at ambient temperature and pressure. At the end of the reaction the catalyst was filtered on Celite, washing the filter with a little ethyl acetate, and the solvent was then evaporated in vacuo and the residue was recrystallized from ethyl acetate and hexane.

Workup

  1. customAt the end of the reaction the catalyst
  2. filtrationwas filtered on Celite
  3. washwashing the
  4. filtrationfilter with a little ethyl acetate
  5. customthe solvent was then evaporated in vacuo
  6. customthe residue was recrystallized from ethyl acetate and hexane

Sources & evidence

ORD record
ord-3f84f91fd0c44ffc8bad4880e0f0f325
Source dataset
uspto-grants-1989_11
Patent number
US04879311

Reaction notes

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