Trifluoroacetic acid methylene chloride → HCID 131716190, compound

HRID 1638349Notes

Reaction equation

HRID 1638349 reaction equation
[NH:1]([C:14]([O:16][CH2:17][CH:18]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]2[C:19]1=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:15])[C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4](=[O:10])[O:5]C(C)(C)C.[CH3:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][NH-:41])=[CH:35][CH:34]=1.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[NH:1]([C:14]([O:16][CH2:17][CH:18]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]2[C:19]1=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:15])[C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4](=[O:5])[OH:10].[CH3:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][NH-:41])=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 131716191HCID 131716191, compound

Product 1

HCID 131716190HCID 131716190, compound

Procedure

Fmoc-Asp(OtBu)-2-(4-methoxyphenyl)ethyl amide (5.44 g; 10 mmoles) was treated with 50% TFA/CH2Cl2 for 90 minutes at room temperature. The solvent was evaporated and the residue was triturated with ethyl ether/petroleum ether. The precipitate was dried and used without further purification.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was triturated with ethyl ether/petroleum ether
  3. customThe precipitate was dried
  4. customused without further purification

Sources & evidence

ORD record
ord-464d49348f1a43b288edbbe2618256e8
Source dataset
uspto-grants-1989_11
Patent number
US04879313

Reaction notes

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