Ethanol → Ethyl trifluoroacetate
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8](O)[CH3:9].S(=O)(=O)(O)O>O>[F:1][C:2]([F:7])([F:6])[C:3]([O:5][CH2:8][CH3:9])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
in a first stage, trifluoroacetic acid is brought into contact with a slight excess of ethanol in the presence of concentrated sulfuric acid and a solvent, the solvent having a boiling point higher than that of trifluoroacetic acid and specific gravity relative to water less than 1 and which solvent does not form an azeotrope with ethyl trifluoroacetate, and then carrying out a phase separation and removing the sulfuric layer, followed, if required, by an additional stage in which concentrated sulfuric acid is added to complete the esterification;
Sources & evidence
- ORD record
- ord-3fba8e3a3ffa4cc6876543563eeba410
- Source dataset
- uspto-grants-1989_11
- Patent number
- US04879407
Reaction notes
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