Dicyclohexylcarbodiimide → 1,5-Dihydro-4,1-benzoxazepin-2(3H)-one

HRID 1638543Notes

Reaction equation

HRID 1638543 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][O:5][CH2:6][C:7](O)=[O:8].C1(N=C=NC2CCCCC2)CCCCC1>CO>[O:8]=[C:7]1[CH2:6][O:5][CH2:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]=2[NH:1]1

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 19836746HCID 19836746, compound

Product 1

HCID 158877541,5-Dihydro-4,1-benzoxazepin-2(3H)-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g o-amino-benzyloxy acetic acid and 1.1 g dicyclohexyl carbodiimide were stirred in 15 ml refluxing methanol for 8 hours. The mixture was evaporated, and the residue was stirred with 50 ml acetone and filtered, whereafter the filtrate was evaporated to give the title compound. M.p. 160°-165° C.

Workup

  1. customThe mixture was evaporated
  2. filtrationfiltered, whereafter the filtrate
  3. customwas evaporated

Sources & evidence

ORD record
ord-5e17cb2132c54838b5d8997f49d230dc
Source dataset
uspto-grants-1989_11
Patent number
US04880799

Reaction notes

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