Dicyclohexylcarbodiimide → 1,5-Dihydro-4,1-benzoxazepin-2(3H)-one

Participants

Reaction Steps

1 g o-amino-benzyloxy acetic acid and 1.1 g dicyclohexyl carbodiimide were stirred in 15 ml refluxing methanol for 8 hours. The mixture was evaporated, and the residue was stirred with 50 ml acetone and filtered, whereafter the filtrate was evaporated to give the title compound. M.p. 160°-165° C.

Provenance & Evidence