Sodium Hydroxide → HCID 15044919, compound

HRID 1638545Notes

Reaction equation

HRID 1638545 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15])[CH3:7])C.[OH-].[Na+]>>[CH3:7][N:6]1[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:4](=[O:3])[CH2:5]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19836753HCID 19836753, compound

Product 1

HCID 15044919HCID 15044919, compound

Conditions

Temperature
150 °C

Procedure

2.0 g N-(o-aminobenzyl)sarcosine ethyl ester was dissolved in 40 g polyphosphoric acid and the mixture was heated to 150° C. for two hours, then cooled and charged with 300 ml icewater. pH was adjusted to 8 with 50% NaOH and the mixture was extracted with dichloromethane. The organic phase was dried over Na2SO4 and evaporated to give the title compound. M.p. 113°-114° C.

Workup

  1. temperaturecooled
  2. additioncharged with 300 ml icewater
  3. extractionthe mixture was extracted with dichloromethane
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-bc03c17b06d245aeacabfe7fc236d8b7
Source dataset
uspto-grants-1989_11
Patent number
US04880799

Reaction notes

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