Sodium Hydroxide → HCID 15044919, compound

Participants

Reaction Conditions

Reaction Steps

2.0 g N-(o-aminobenzyl)sarcosine ethyl ester was dissolved in 40 g polyphosphoric acid and the mixture was heated to 150° C. for two hours, then cooled and charged with 300 ml icewater. pH was adjusted to 8 with 50% NaOH and the mixture was extracted with dichloromethane. The organic phase was dried over Na2SO4 and evaporated to give the title compound. M.p. 113°-114° C.

Provenance & Evidence