HCID 86743501, compound → HCID 18635749, compound

HRID 1638556Notes

Reaction equation

HRID 1638556 reaction equation
CS(O[CH2:6][C@@H:7]1[O:12][C:11]2[CH:13]=[CH:14][CH:15]=[C:16]([C:17]([NH2:19])=[O:18])[C:10]=2[O:9][C@H:8]1[CH2:20]OS(C)(=O)=O)(=O)=O>C(N)C1C=CC=CC=1>[C:16]1([CH2:17][N:19]2[CH2:20][C@@H:8]3[O:9][C:10]4[C:16]([C:17]([NH2:19])=[O:18])=[CH:15][CH:14]=[CH:13][C:11]=4[O:12][C@H:7]3[CH2:6]2)[CH:10]=[CH:11][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 1

HCID 86743501HCID 86743501, compound

Product 1

HCID 18635749HCID 18635749, compoundYield 189.6%

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

A solution of Compound D (6.76 g) in benzylamine (10 ml) was heated to 120° for 10 minutes. The warm (85°) solution was poured into stirred, distilled water (300 ml) at room temperature. An oil deposited which quickly solidified. After 1 hour's brisk stirring, the buff coloured particulate solid was collected, washed with water and dried to give the title compound 5.03 g, m.pt 155°-165°.

Workup

  1. temperatureThe warm (85°) solution
  2. additionwas poured
  3. distillationdistilled water (300 ml) at room temperature
  4. customwas collected
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-f376375ad7fe4f6e8fb5aeef16e7281c
Source dataset
uspto-grants-1989_11
Patent number
US04880801

Reaction notes

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