反应详情

To a solution of (3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine-4-carboxylic acid 9H-fluorene-9-ylmethyl ester (950 mg) in acetonitrile (16 mL) was added diethylamine (4 mL), and the resultant solution was stirred for 1 hour at room temperature. The reaction solution was then diluted with toluene (20 mL), and solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography (heptane/ethyl acetate 4/1→1/1), to thereby obtain the titled compound (424 mg). The physical properties of this crude product were as follows.

1. customwas removed by distillation under reduced pressure
2. customThe resulting residue was purified by silica gel column chromatography (heptane/ethyl acetate 4/1→1/1)