Ethyl 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate → Ethyl 2-methyl-1-piperazinecarboxylate
反応式
[CH3:1][CH:2]1[CH2:7][N:6](CC2C=CC=CC=2)[CH2:5][CH2:4][N:3]1[C:15]([O:17][CH2:18][CH3:19])=[O:16].[H][H]>[Pd].CO>[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]参加物
5
実験手順
A mixture of 21 parts of ethyl 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was distilled twice, yielding 23 parts (100%) of ethyl 2-methyl-1-piperazinecarboxylate; bp. 95°-98° C. at 66.5 Pa (int. 37).
後処理
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated
- distillationThe residue was distilled twice
出典と根拠
- ORDレコード
- ord-117f1e85eb494b4e996a5bf1b779697a
- 出典データセット
- uspto-grants-1989_11
- 特許番号
- US04880808
反応ノート
読み込み中…