Hydrochloric Acid → HCID 19841387, compound

HRID 1638700Notes

Reaction equation

HRID 1638700 reaction equation
C([CH:4]1[CH:9]2[NH:10][C:11]3[CH:12]=[N:13][C:14]4[C:19]([C:20]=3[C:8]2=[C:7]([CH3:22])[NH:6][CH2:5]1)=[CH:18][CH:17]=[C:16]([Cl:21])[CH:15]=4)(=O)C.Cl>>[Cl:21][C:16]1[CH:15]=[C:14]2[C:19]([C:20]3[C:8]4=[C:7]([CH3:22])[NH:6][CH2:5][CH2:4][CH:9]4[NH:10][C:11]=3[CH:12]=[N:13]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19841391HCID 19841391, compound

Product 1

HCID 19841387HCID 19841387, compoundYield 72.6%

Procedure

A mixture prepared from 17.5 g of 8-acetyl-3-chloro-11-methyl-7,8,9,10-tetrahydro-pyrido[3',4':4,5]pyrrolo[2,3-c]quinoline and 125 ml of concentrated hydrochloric acid was refluxed for one hour. The product precipitated as hydrochloride salt and it was recovered by filtration. The salt was suspended in water and the mixture was basified with 50% sodium hydroxide solution. The resultant solid was recovered by filtration and recrystallized from isopropanol to give 11 g of crystalline solid with a melting point of 209°-212° C.

Workup

  1. temperaturewas refluxed for one hour
  2. customThe product precipitated as hydrochloride salt and it
  3. filtrationwas recovered by filtration
  4. filtrationThe resultant solid was recovered by filtration
  5. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-432700446da240b095fb3add4afe988c
Source dataset
uspto-grants-1989_11
Patent number
US04880818

Reaction notes

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