反应详情

A mixture of 2.6 g of 2-nitroimino-imidazolidine, 3.0 g of anhydrous potassium carbonate and 30 ml of dry acetonitrile was stirred at room temperature for 30 minutes. Then, 2.7 g of 1-chloro-3,3-dimethyl-2-butanone were added to the mixture under stirring at room temperature. The reaction mixture was heated and refluxed for 1 hour. The acetonitrile was distilled off under a reduced pressure, and the residue was admixed with water. The aimed product was separated by filtration. The crystalline product was washed in ether and dried. 3.5 g of 1-(3,3-dimethyl-2-butanon-1-yl)-2-nitroimino-imidazolidine were obtained. mp. 158°-159° C.

1. stirringunder stirring at room temperature
2. temperatureThe reaction mixture was heated
3. temperaturerefluxed for 1 hour
4. distillationThe acetonitrile was distilled off under a reduced pressure
5. customThe aimed product was separated by filtration
6. washThe crystalline product was washed in ether
7. customdried