2-Chlorobenzenesulfonyl chloride → HCID 14516525, compound

HRID 1638892Notes

Reaction equation

HRID 1638892 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[N:16][C:17]([CH3:24])=[CH:18][C:19]=2[CH3:23])[N:14]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[N:16][C:17]([CH3:24])=[CH:18][C:19]=2[CH3:23])[N:14]=1)(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 973655,7-Dimethyl-1,8-naphthyridin-2-ylamine

Product 1

HCID 14516525HCID 14516525, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

At an internal temperature of 40° to 50° C., 7.5 g (35.5 mmol) of 2-chlorobenzenesulfonyl chloride was slowly dripped, while stirring, into a suspension of 4.1 g (23.6 mmol) of commercially available 2-amino-5,7-dimethyl-1,8-naphthyridine in 100 ml of anhydrous pyridine.

Sources & evidence

ORD record
ord-ce018868c05a4f729d1e8776046cb5d5
Source dataset
uspto-grants-1989_11
Patent number
US04881969

Reaction notes

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