Hydrochloric Acid → HCID 19839387, compound

HRID 1638903Notes

Reaction equation

HRID 1638903 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[C:12]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:11]([C:17]([OH:19])=[O:18])[CH:10]=[N:9]2)[CH:5]=[CH:4][CH:3]=1.Cl.[CH2:21](O)[CH3:22]>>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[C:12]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:11]([C:17]([O:19][CH2:21][CH3:22])=[O:18])[CH:10]=[N:9]2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 19839462HCID 19839462, compound

Product 1

HCID 19839387HCID 19839387, compound

Procedure

Next, the above sulfonamide was introduced in ethanol saturated with hydrogen chloride, and, while stirring, heated under reflux for 7 hours. After solvent was evaporated, water was added, followed by extraction with chloroform. Extract liquid was evaporated to dryness to obtain 0.62 g of the title compound. m.p.: 125° to 128° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 7 hours
  3. customAfter solvent was evaporated
  4. additionwater was added
  5. extractionfollowed by extraction with chloroform
  6. extractionExtract liquid
  7. customwas evaporated to dryness

Sources & evidence

ORD record
ord-b8b35d22cfab4b7c8b2ab5db38f96e9c
Source dataset
uspto-grants-1989_11
Patent number
US04881965

Reaction notes

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