Hydrazine hydrate (1:1) → HCID 19839368, compound

HRID 1638905Notes

Reaction equation

HRID 1638905 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8](=[O:13])(=[O:12])[N:9]([CH3:11])[CH3:10])[N:3]=1.O.[NH2:15][NH2:16]>C(O)CCC>[CH3:10][N:9]([CH3:11])[S:8]([C:4]1[N:3]=[C:2]([NH:15][NH2:16])[CH:7]=[CH:6][CH:5]=1)(=[O:13])=[O:12]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19839452HCID 19839452, compound

Product 1

HCID 19839368HCID 19839368, compoundYield 51.9%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

To 12 g of 2-chloro-6-dimethylsulfamoylpyridine were added 30 ml of n-butanol and 4 g of hydrazine hydrate. The mixture was stirred at room temperature for 30 minutes, followed by heating under reflux for 18 hours. After cooling, crystals obtained were filtered and washed with water to obtain 6.1 g of 6-dimethylsulfamoyl-2-hydrazinopyridine. m.p.: 117° to 120° C.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 18 hours
  3. temperatureAfter cooling
  4. customcrystals obtained
  5. filtrationwere filtered
  6. washwashed with water

Sources & evidence

ORD record
ord-5fcf5b8b8ed543dea861711ee29e6272
Source dataset
uspto-grants-1989_11
Patent number
US04881965

Reaction notes

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