Methanesulfonic Acid → HCID 19839377, compound

HRID 1638907Notes

Reaction equation

HRID 1638907 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[C:8]=1[S:9]([NH2:12])(=[O:11])=[O:10])([OH:3])=O.CS(O)(=O)=O.[CH2:24](O)[CH:25]=[CH2:26]>>[CH2:26]([C:1]([C:4]1[CH:5]=[N:6][N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[C:8]=1[S:9]([NH2:12])(=[O:11])=[O:10])=[O:3])[CH:25]=[CH2:24]

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 7858Allyl AlcoholHCID 19839491HCID 19839491, compound

Product 1

HCID 19839377HCID 19839377, compound

Conditions

Temperature
110 °C

Procedure

To a mixture of 2.2 of 4-carboxy-1-(2-pyridyl)pyrazole-5-sulfonamide and 20 ml of allyl alcohol, 1 ml of methanesulfonic acid was added, followed by stirring at 110° C. for 18 hours. The reaction mixture was concentrated under reduced pressure, and purified by silica gel chromatography to obtain 0.7 g of the title compound. m.p.: 140° to 142° C.

Workup

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-b5e63523a580431f8251263b2419752f
Source dataset
uspto-grants-1989_11
Patent number
US04881965

Reaction notes

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