反应详情

To a 70 ml acetone mixture of 8.5 g of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide and 6.0 g of anhydrous potassium carbonate, added was 3.3 g of n-butylisocyanate at room temperature, followed by heating under reflux for 3 hours. After the reaction was completed, acetone was evaporated under reduced pressure, and then the residue was emptied into ice water to filter insolbles off, and then the filtrate was precipitated with hydrochloric acid. Crystals precipitated was filtered, washed with water and dried to obtain 10.8 g of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide. m.p.: 180° to 181° C.

1. additionadded
2. customat room temperature
3. temperatureby heating
4. temperatureunder reflux for 3 hours
5. customacetone was evaporated under reduced pressure
6. filtrationto filter insolbles off, and then the filtrate
7. customwas precipitated with hydrochloric acid
8. customCrystals precipitated
9. filtrationwas filtered
10. washwashed with water
11. customdried