Acetic Acid → HCID 17997097, compound

HRID 1638964Notes

Reaction equation

HRID 1638964 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12](C(O)=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[C:18]([OH:21])(=[O:20])C.Br>O>[OH:2][C:3]1[CH:4]=[C:5]([C:18]([OH:21])=[O:20])[C:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 27595524'-Methoxy(1,1'-biphenyl)-4-carboxylic acid

Product 1

HCID 17997097HCID 17997097, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

25 g of 4'-methoxybiphenyl-4-carboxylic acid, 1 liter of acetic acid and 200 ml of 48% hydrobromic acid were refluxed for 12-14 hours and then the mixture was thrown into 2.5 liter of water. After cooling, the crystals were collected to obtain 4-hydroxybiphenylcarboxylic acid with a melting point of 288°-291° C. and at a yield of 90-95%.

Workup

  1. temperatureAfter cooling
  2. customthe crystals were collected

Sources & evidence

ORD record
ord-f47b6082a69e411ba96d26d09db533cf
Source dataset
uspto-grants-1989_11
Patent number
US04882085

Reaction notes

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