反应详情

4-Methyl-3-oxopentanonitrile (A) was dissolved in ethanol (140 ml) and stirred at room temperature. Hydrazine hydrate (15.7 g) was added and the resulting mixture was stirred for 1 hour at room temperature, followed by heating under refluxing for 5 hours. The solvent was distilled off under reduced pressure and the residue was subjected to distillation under reduced pressure (133°-153° C./0.06 mmHg) to obtain 33.3 g (87%) of 5-amino-3-(1-methylethyl)pyrazole (B).

1. stirringthe resulting mixture was stirred for 1 hour at room temperature
2. temperatureby heating
3. temperatureunder refluxing for 5 hours
4. distillationThe solvent was distilled off under reduced pressure
5. distillationthe residue was subjected to distillation under reduced pressure (133°-153° C./0.06 mmHg)