Thionyl Chloride → HCID 14622462, compound

HRID 1639008Notes

Reaction equation

HRID 1639008 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9]([CH2:15]O)=[N:8][CH:7]=[CH:6]2.S(Cl)([Cl:19])=O>C(Cl)Cl>[Cl:19][CH2:15][C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:12]([O:13][CH3:14])[CH:11]=2)[CH:6]=[CH:7][N:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 14622433(6,7-Dimethoxyisoquinolin-1-yl)methanol

Product 1

HCID 14622462HCID 14622462, compoundYield 147.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 306.3 mg of 6, 7-dimethoxyisoquinolin-1-ylmethanol (1.397 mmol) were added 20 ml of dry CH2Cl2 and 665 mg of thionyl chloride (5.95 mmol) and the mixture was stirred for 2 hours at room temperature. The reaction solution was concentrated to give 490mg of 1-chloro-(6,7-dimethoxyisoquinolin-1-yl)methane (III-1) as brown crystals.

Workup

  1. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-5ab8c4bc1dbe40f58d3fc486404e70b4
Source dataset
uspto-grants-1989_11
Patent number
US04882338

Reaction notes

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