反应详情

2.5 g of 5-hydroxy-pyrrolidin-2-one and 1.25 g of Amberlite IR 120H are heated to 65° C. for 3 hours in 55 cm3 of 1-pentanol. The resin is filtered off, and the remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar. The residue is chromatographed on silica (eluent: ethyl acetate), and 2.68 g of the expected product is obtained. m.p. 42°-43° C.

1. filtrationThe resin is filtered off
2. distillationthe remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar
3. customThe residue is chromatographed on silica (eluent: ethyl acetate)