反应详情

3 g of 5-hydroxy-pyrrolidin-2-one and 1.5 g of Amberlite resin IR 120H in 60 cm3 of n-decanol are agitated at 60° C. for 3 hours. The resin is filtered off and the solvent is eliminated by distilling at 60° C. under 0.4 mm of Hg. The residue is taken up in 50 cm3 of n-hexane, kept for 24 hours at -5° C./-10° C., separated, and 3.5 g of the expected product is obtained, m.p. 44°-46° C. After re-crystallizing from n-hexane, m.p. 48°-49° C.

1. filtrationThe resin is filtered off
2. distillationby distilling at 60° C. under 0.4 mm of Hg
3. custom/-10° C., separated