反应详情

温度

40 °C

To a solution of 1 mole (158 g) of 4-phenylphenol, 100 g of sodium hydroxide and 400 ml of water was added 1 mole (143.02 g) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr, cooled and extracted with 300 ml of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g of a white crystalline solid which melted at 123°-124° C.

1. temperatureThe resulting mixture was heated at 68° C. in a steam bath for 6 hr
2. temperaturecooled
3. extractionextracted with 300 ml of chloroform
4. extractionThe chloroform extract
5. washwas washed with water to neutrality
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated to dryness
8. customThe solid residue was recrystallized with isopropanol