3-(Trifluoromethyl)phenol → 2-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

Temperature

65 °C

To a mixture of 0.5 mole (75 g) of m-trifluoromethylphenol, 1 mole (56 g) of potassium hydroxide, 100 ml of water and 400 ml of isopropanol was added 0.6 mole (84 g) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr, mixed with 2 liters of water, and extracted with 400 ml of isopropyl ether. The ether extract was washed with 0.5 N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm solidified at room temperature and melted at 50°-52° C.

1. customThe resulting reaction mixture
2. extractionextracted with 400 ml of isopropyl ether
3. extractionThe ether extract
4. washwas washed with 0.5 N sodium hydroxide
5. dry with materialwith water, dried over sodium sulfate
6. distillationdistilled under reduced pressure
7. distillationThe distillate which was collected at 120°-124° C./0.01 mm
8. customsolidified at room temperature

ORD record

ord-9e4f49efb4c84a2ba8fc5662ce89bede

Source dataset

uspto-grants-1989_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04882330