HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 1-Phenoxy-4-[4-(4-fluorophenyl)-1-piperazinyl]-2-butanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| Reactant | 4-Chloro1-phenoxy-2-butanol | HCID 13120342 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-Phenoxy-4-[4-(4-fluorophenyl)-1-piperazinyl]-2-butanol | HCID 14422839 | — |
Reaction Steps
This compound was prepared according to the procedure of Example 6. A mixture of 3.6 g (0.02 mole) of 1-(4-fluorophenyl)piperazine, 4.0 g (0.02 mole) of 4-chloro-1-phenoxy 2-butanol and 5.3 g (0.05 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 5.1 g (74%) of offwhite powder, m.p. 97°-99° C. Recrystallizing solvent used was isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04882330 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-09bca7d0ca8340cba0f663eeb92cc099 |
| Source note | uspto-grants-1989_11 |