Isopropanol → 1-Phenoxy-4-[4-(4-methoxyphenyl)-1-piperazinyl]-2-butanol

HRID 1639080Notes

Reaction equation

HRID 1639080 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl[CH2:16][CH2:17][CH:18]([OH:27])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[Na+].[Na+].C(O)(C)C>C(O)CCC>[O:20]([CH2:19][CH:18]([OH:27])[CH2:17][CH2:16][N:12]1[CH2:13][CH2:14][N:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

6

Reactant 4

HCID 3776IsopropanolHCID 10340Sodium CarbonateHCID 2697221-(4-Methoxyphenyl)piperazineHCID 131203424-Chloro1-phenoxy-2-butanol

Product 1

HCID 144228401-Phenoxy-4-[4-(4-methoxyphenyl)-1-piperazinyl]-2-butanol

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 6. A mixture of 4.8 g (0.025 mole) of 1-(4-methoxyphenyl)piperazine, 5.0 g (0.025 mole) of 4-chloro1-phenoxy-2-butanol and 8.0 g (0.075 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 6.4 g (72%) of tan towder., m.p. 95°-97° C. Recrystallizing solvent used was isopropyl alcohol.

Workup

  1. customThis compound was prepared
  2. customgave 6.4 g (72%) of tan towder

Sources & evidence

ORD record
ord-4b84c996cc47484fb3cfcf1cb0e4f246
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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