1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 14422844, compound

HRID 1639082Notes

Reaction equation

HRID 1639082 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:4]=1.Cl[CH2:18][CH2:19][CH:20]([OH:29])[CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[O:22]([CH2:21][CH:20]([OH:29])[CH2:19][CH2:18][N:12]1[CH2:13][CH2:14][N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:10][CH2:11]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 3

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 10340Sodium CarbonateHCID 131203424-Chloro1-phenoxy-2-butanol

Product 1

HCID 14422844HCID 14422844, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 6. A mixture of 3.5 g (0.015 mole) of N-(α, α, αtrifluoro-m-tolyl)piperazine, 3.0 g (0.015 mole) of 4-chloro1-phenoxy-2-butanol and 5.3 g (0.05 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 3.9 g (66%) of white powder, m.p. 83°-84° C. The recrystallizing solvent used in isopropyl alcohol.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-856ddb7d74d34434808ecd72af5863cc
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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