Potassium Iodide → Hydrochloric Acid

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 25. A mixture of 7.7 g (0.03 mole) of 4-chloro-1-[4-(1,1-dimethylethyl)phenoxy]-2-butanol, 5.0 g (0.03 mole) of 1-phenylpiperazine, 16.0 g (0.15 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloric acid salt was formed in 2-propanol saturated with hydrogen chloride, and the collected solid was recrystallized from 2-propanolmethanol-water to give 6.0 g (48%) of white, crystalline solid, m.p. 190°-193° C.

Provenance & Evidence