Potassium Iodide → Hydrochloric Acid

HRID 1639089Notes

Reaction equation

HRID 1639089 reaction equation
[Cl:1][CH2:2][CH2:3][CH:4]([OH:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:9][CH:8]=1.[C:18]1([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CC(O)C.C(O)CCC>[ClH:1].[C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][CH:4]([OH:17])[CH2:3][CH2:2][N:27]2[CH2:28][CH2:29][N:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:25][CH2:26]2)=[CH:8][CH:9]=1)([CH3:16])([CH3:15])[CH3:14].[ClH:1]

Participants

8

Reactant 4

HCID 4875Potassium IodideHCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 14422835HCID 14422835, compound

Product 2

HCID 313Hydrochloric AcidHCID 14422902HCID 14422902, compound

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 3776IsopropanolSolvent

Procedure

This compound was prepared according to the procedure of Example 25. A mixture of 7.7 g (0.03 mole) of 4-chloro-1-[4-(1,1-dimethylethyl)phenoxy]-2-butanol, 5.0 g (0.03 mole) of 1-phenylpiperazine, 16.0 g (0.15 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloric acid salt was formed in 2-propanol saturated with hydrogen chloride, and the collected solid was recrystallized from 2-propanolmethanol-water to give 6.0 g (48%) of white, crystalline solid, m.p. 190°-193° C.

Workup

  1. customThis compound was prepared
  2. customgave a golden oil as residue

Sources & evidence

ORD record
ord-31943be5f5b0400ca22b9d491b10231b
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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