Potassium Iodide → HCID 14422890, compound

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 25. A mixture of 5.8 g (0.0267 mole) of 4-chloro-1-(4-fluorophenoxy)-2-butanol, 5.1 g (0.0267 mole) of 1-(4-methoxyphenyl)piperazine, 9.4 g (0.089 mole) of anhydrous sodium carbonate, and 0.16 g of potassium iodide in a total volume of 200 ml of 1-butanol gave a brown oil. Upon trituration with petroleum ether (30°-60° C.), the oil solidified. The collected solid was recrystallized from isopropyl ether to yield 6.4 g (64%) of white, crystalline solid, m.p. 78°-80° C.

Provenance & Evidence