HCID 3078928, compound → HCID 23714429, compound

HRID 1639131Notes

Reaction equation

HRID 1639131 reaction equation
[C:1]1([S:7]([NH:10][CH2:11][CH2:12][S:13][CH:14]2[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[CH2:18][O:17][C:16]3[CH:25]=[CH:26][C:27]([C:29]([OH:31])=[O:30])=[CH:28][C:15]2=3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+:34]>CO>[OH2:8].[C:1]1([S:7]([NH:10][CH2:11][CH2:12][S:13][CH:14]2[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[CH2:18][O:17][C:16]3[CH:25]=[CH:26][C:27]([C:29]([O-:31])=[O:30])=[CH:28][C:15]2=3)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:34]

Participants

4

Reactant 2

HCID 3078928HCID 3078928, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 23714429HCID 23714429, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 1b, 3.3 g, obtained in Example 21 was suspended in 100 ml of methanol and sodium methoxide was added to the solution followed by stirring for about an hour. The solvent was distilled off under reduced pressure and the resulting crude product was solidified by isopropyl ether to give 2.3 g of the desired compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-59eec6216fd14c5683f428212082a109
Source dataset
uspto-grants-1989_11
Patent number
US04882351

Reaction notes

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