Ammonia → HCID 19840378, compound

HRID 1639137Notes

Reaction equation

HRID 1639137 reaction equation
[C:1]([C:3]([C:6]1[CH:20]=[CH:19][C:9]2[N:10]=[C:11]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[NH:12][C:8]=2[CH:7]=1)([CH3:5])[CH3:4])#[N:2].S(=O)(=O)(O)[OH:22].N>>[NH2:2][C:1]([C:3]([C:6]1[CH:20]=[CH:19][C:9]2[N:10]=[C:11]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[NH:12][C:8]=2[CH:7]=1)([CH3:5])[CH3:4])=[O:22]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 14153041HCID 14153041, compound

Product 1

HCID 19840378HCID 19840378, compound

Procedure

3.7 g. of the 5-(2-cyanopropan-2-yl)-2-(4-pyridinyl)benzimidazole (prepared in Example 15) are stirred for 3 hours at 50° C. in 40 ml. 80% sulphuric acid, the compound thereby slowly going into solution. The reaction mixture is then poured on to ice, rendered alkaline with ammonia, filtered off with suction and recrystallised from ethanol. There are obtained 2.4 g. (61% of theory) of the title compound in the form of colourless crystals; m.p. 274°-276° C.

Workup

  1. additionThe reaction mixture is then poured on to ice
  2. filtrationfiltered off with suction
  3. customrecrystallised from ethanol
  4. customThere are obtained 2.4 g

Sources & evidence

ORD record
ord-a8bdd47d30f74d008e32c30c68ec8e34
Source dataset
uspto-grants-1989_11
Patent number
US04882342

Reaction notes

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