反应详情

1.45 g. of the compound prepared in Example 26 is boiled under reflux for 48 hours in 35 ml. ethanol and 35 ml. concentrated hydrochloric acid. The solvent is removed in a vacuum and the residue is dissolved in water and neutralised with 2N aqueous ammonia solution. The substance which precipitates out is filtered off with suction. There is obtained 1.1 g. of the title compound; m.p. 45°-48° C.

1. temperatureunder reflux for 48 hours in 35 ml
2. customThe solvent is removed in a vacuum
3. dissolutionthe residue is dissolved in water and neutralised with 2N aqueous ammonia solution
4. customThe substance which precipitates out
5. filtrationis filtered off with suction
6. customThere is obtained 1.1 g