4-Bromo-2,6-difluoroaniline → 4-Amino-3,5-difluorobenzonitrile

HRID 1639194Notes

Reaction equation

HRID 1639194 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[Cu][C:12]#[N:13]>CN1CCCC1=O>[C:12]([C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1)#[N:13]

Participants

4

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 178418546HCID 178418546, compound

Product 1

HCID 2804674-Amino-3,5-difluorobenzonitrile

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

reacting 4-bromo-2,6-difluoroaniline with copper (I) cyanide and N-methyl-2-pyrrolidone to yield 4-cyano-2,6-difluoroaniline;

Sources & evidence

ORD record
ord-5425e4767b4c4935aaf218dfe3de3ec8
Source dataset
uspto-grants-1989_11
Patent number
US04883609

Reaction notes

Loading…